Telomeres in human sperm nucleus are clustered at the nuclearperiphery.
2
First, chromatin is repositioned away from the nuclearperiphery in response to global acetylation.
3
The nuclearperiphery (NP) plays a substantial role in chromatin organization.
4
Transcriptional activation of this promoter occurs at the nuclearperiphery in association with chromosome-end clusters.
5
The nuclearperiphery has conventionally been considered as a zone of inactive chromatin and transcriptional repression.
6
In addition to unattached kinetochores, MAD-1 localized between separating meiotic chromosomes and to the nuclearperiphery.
7
Previously published image-based studies had suggested that HIV-1 prefers to integrate into chromatin that associates spatially with the nuclearperiphery.
8
It has been suggested that chromatin at the nuclearperiphery could act to shield DNA sequences in the nuclear interior from damage.
9
Moreover, the nuclearperiphery itself is heterogeneous, with microdomains of differing compositions, associating with different genomic regions and probably having differential effects on genome function.
10
DIP1, similar to other nuclear proteins in eukaryotes, is localized to the nuclearperiphery and chromatin domain in all nuclei, but disappears at the metaphase.