Meanings of null genotype in anglès

An association was found between GSTT1- null genotype and endometriosis in the Hans, but not in the Uygurs.

Our results suggest that the GSTM1 null genotype may play a role in post-menopausal breast cancer development.

These data suggest that women with the GSTM1 null genotype are not at increased risk of cervical cancer.

Conclusions: No evidence was found to suggest an association between GSTM1- null genotype and endometriosis in the Hans and Uygurs.

The homozygous null genotype was not overrepresented in either those with a single melanoma or in the NBCCS cases.

The homozygous null genotype at this locus has been associated with increased susceptibility to malignancy, including some skin cancers.

It was found that 53% of cases and 57% of controls had the GSTM1 null genotype.

On the contrary, a suggestion of a decreased risk of breast cancer associated with the GSTT1 null genotype was observed among premenopausal women.

Some studies have reported an association of the GSTM1- null genotype with the risk of smoking-related cancers, such as lung, bladder, and colon cancer.

The frequency of the null genotype was present in 0.11 and 0.12 of Caucasian and African American controls, respectively.

The higher incidence of GSTM1 null genotype observed in female patients, suggests a possible role of the GSTM1 detoxification pathway in a gender-dependent manner.

The frequency of the GSTM1- null genotype in controls was approximately 57%; this differed little in relation to age, sex and smoking status.

There were null genotypes in some samples for six of the markers.

The null genotypes were found to be more frequent in women than in men.

The aim of this study is to investigate GSTM1 and GSTT1 null genotypes in an Iranian population.

We applied an alternative approach to assess the controversial evidence for the role of GSTM1 and GSTT1 deficiencies ( null genotypes) in cancer susceptibility.