Significats de oral absorption en anglès

The oral absorption of FK is rapid but variable in dogs.

The oral absorption of FK506 in solid dispersion formulation was studied in rats.

When dosed as the sodium salt, these compounds displayed excellent oral absorption and pharmacokinetic properties.

However, relevance of the phase separation behavior to oral absorption from ASDs is still not well understood.

Further, we explore the mechanisms behind the improved oral absorption of poorly soluble drugs promoted by MSNs.

The objective of this study was to investigate the mechanisms of oral absorption of BMS-262084 in rats.

Conclusion: This study indicates that intragastric pH and salt solubility-dissolution are important in the oral absorption of zinc.

Pharmacokinetic analyses showed a proportional increase in exposure with dose, rapid oral absorption, and a half-life of approximately 3 hours.

Usually for drugs with such low solubility values, their oral absorption and hence bioavailability are limited by their dissolution characteristics.

Merrion says clinical studies have shown oral absorption can be improved by up to 46 times on a wide range of drugs.

It was stable in simulated gastrointestinal fluid, and readily penetrated across differentiated Caco-2 cell model of intestinal barrier, suggesting good oral absorption.

With a slow oral absorption profile, 7l accumulates in the eye to maintain a high concentration after dosing with higher levels than in plasma.

Multiple approaches such as mathematical deconvolution and mechanistic oral absorption models have been used to predict in vivo drug dissolution in the gastrointestinal (GI) tract.

The cumulative urinary excretion of FBAL was about 80% of the total dose, and the oral absorption of TT-62 was thus thought to be good.

Oral absorption of quinidine was described by a zero order process with a bioavailability of 0.78.

Oral absorption was fairly rapid; median Tmax was 2.0 to 4.0 hours after a single dose.