Significats de oxidize lipids en anglès

All three PON enzymes are able to degrade oxidized lipids and protect against oxidative stress.

These data provide further evidence that the induction of inflammatory molecules by oxidized lipids is selective.

We measured plasma and cellular markers of monocyte activation, T-cell activation, oxidized lipids and gut integrity.

Functional changes induced by oxidized lipids in endothelial cells are early events in the pathogenesis of atherosclerosis.

These HDL mimetic peptides are much more effective in removing the oxidized phospholipids and other oxidized lipids.

The liver oxidizes lipids, but can also package excess lipid for secretion to and storage in other tissues, such as adipose.

The redox-sensitive transcription factor Nrf2 is the major regulator of the fibroblast stress response to ultraviolet radiation or exposure to oxidized lipids.

The activities of the HDL-associated PON1 and several other anti-inflammatory factors in HDL are in turn negatively regulated by these oxidized lipids.

Both UVA-1 irradiation and treatment with oxidized lipids led to increased nuclear accumulation and DNA binding of NRF2.

In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.

In rabbits, mice, and humans there appears to be an increase in the formation of these oxidized lipids during the acute phase response.

Interaction of oxidized lipids with pattern recognition receptors and activation of the inflammasome by cholesterol crystals drive macrophages toward an inflammatory M1 phenotype.

Targeting the formation or accumulation of oxidized biomolecules, particularly oxidized lipids, in immune cells and mitochondria could be beneficial for age-related inflammation and comorbidities.

Furthermore, indicators of metabolic stress were reflected by low amounts of ATP and NADH and an increased abundance of oxidized lipids derived from lipid breakdown.

The antioxidants present within both LDL and the microenvironments in which LDL is trapped function to prevent the formation of these biologically active, oxidized lipids.

We have developed apoA-I mimetic peptides that are much smaller than apoA-I, and much more effective in removing the oxidized phospholipids and other oxidized lipids.