Significats de pair helical en anglès

Neurofibrillary tangles consist of abnormal protein fibers known as paired helical filaments.

Tau protein, a microtubule-associated protein, is the major component of paired helical filaments.

Each lesion contains the paired helical filament (PHF) as its major fibrous component.

Sarkosyl-insoluble tau showed paired helical and straight filaments, as well as more irregular rope-like filaments.

Many of those cell processes contained abnormal straight or paired helical filaments supporting their neuritic nature.

The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments.

The accumulation of paired helical filaments is one of the most characteristic cellular changes in Alzheimer's disease.

What triggers the formation of paired helical filaments is not known, but neuroinflammation could play a role.

Almost 70% of the neuropil threads contained straight or paired helical filaments with no neurofilaments.

Western blot analysis confirmed that PLC-delta was concentrated in the paired helical filament (PHF)-rich fraction of AD brains.

The present findings further support existing evidence that the paired helical filaments of Alzheimer's disease share antigenic determinants with normal NF.