Significats de phorbol ester en anglès

Staurosporine inhibits cell proliferation and in vivo protein phosphorylation induced by phorbol ester.

The C2 domain-swapped mutants were inactive in phorbol ester-induced membrane translocation.

Such an effect was not seen with inactive phorbol ester.

In contrast, basal and phorbol ester-stimulated PLD activities were not or only slightly reduced.

In the presence of cholesterol sulfate, phorbol ester only weakly enhanced the activity of nPKC eta.

These samples were stimulated ex vivo with phorbol ester and were assayed for PKC activity using this approach.

Plating onto basement membrane matrix and stimulation by phorbol ester were used as in vitro models of angiogenesis.

Inhibition of Fas-mediated cell death by phorbol ester is also observed in other human leukemic T cell lines.

We conclude that the iridals represent a promising structural motif for design of ligands for phorbol ester receptor family members.

Functional studies implicate AP1-1 and AP1-5 in mediating the phorbol ester-dependent increase in promoter activity.

Involucrin mRNA levels increase 10-fold and promoter activity 5-11-fold when differentiation is induced by phorbol ester.

In this report, we show that all these effects are substantially inhibited by the activation of PKC with a phorbol ester.

CD45 redistribution does not require hydrolysis of phosphatidylinositides and cannot be reproduced by the addition of phorbol ester and calcium ionophore.

Raising of intracellular cGMP by 8-bromo-cGMP and activation of protein kinase C by phorbol ester led to an inhibition of secretion.

An important prediction of this hypothesis is that inhibitors of PKC should inhibit these phorbol ester-induced changes in bag cell neuronal excitability.

Activation of PKC using phorbol ester resulted in an increase of adhesive interactions under dynamic and static conditions, whereas its inhibition reduced adhesion.