Nitric oxide (NO) is a key physiological regulator in eukaryotic and prokaryotic organisms.

These data identify TRβ in the VMH as a major physiological regulator of food intake and energy homeostasis.

Conclusions: These data support the concept that GE is an important physiological regulator of pp glucose homeostasis in humans.

Thus, AMP is a true physiological regulator of AMPK, and allosteric regulation is an important component of the overall activation mechanism.