However, most PMTs including more than 60 human PMTs remain to be fully characterized.
2
It is also not trivial to assign unambiguously dynamic methylation events to specific PMTs given their potential redundancy.
3
This review focuses on the decade-long progress in developing complementary chemical tools to elucidate targets of designated PMTs.
4
The current approaches to elucidate the functions of PMTs have been diversified by many emerging chemical biology technologies.
5
PMTS represents a useful model to describe the psychological reactions of parents of newborns operated at birth for a congenital malformation.
6
Protein methyltransferases (PMTs) have emerged as important epigenetic regulators in myriad biological processes in both normal physiology and disease conditions.
7
Because PMTs often function in vivo through forming multimeric protein complexes, dissecting their activities in the native contexts is challenging but relevant.
8
Given the conserved active sites of PMTs, Ab-SAM and its use in BPPM are expected to be transferable to other PMTs for target identification.
9
The robust performance of this SPIA for the four PMTs was validated in a pilot screen of approximately 7,000 compounds.
10
Background: Pediatric medical traumatic stress (PMTS) is a psychological and physiological response of children and their families to pain, serious illness, and invasive medical procedures.
11
PMT-derived alveolar macrophages persisted for at least one year as did therapeutic effects.
12
These markers can be used to determine prognosis and predict response to PMT.
13
Moreover, PMT significantly improves alveolar protein deposition and other critical herPAP disease parameters.
14
PMT and PWR were less equitable and inefficient although feasible in some settings.
15
However, most PMTs including more than 60 human PMTs remain to be fully characterized.
16
The specific PMT inhibitors may constitute a new class of anti-proliferative agents for potential therapeutic use.