Significats de polyketide en anglès

A synthesis of the ABC-rings of the polyketide natural product hexacyclinic acid has been achieved.

The two essential structural components of macrolide antibiotics are the polyketide aglycone and the appended sugars.

Feeding experiments using (13)C-labeled acetate were carried out to confirm that the angucycline core is indeed polyketide-derived.

The present study confirmed the presence of the unusual pathway in the biosynthesis of a hybrid peptide-polyketide natural product.

This result clearly indicated that macrolactone formation proceeds 15-OH oxidation since the linear polyketide is not a substrate for SpnJ.

We also determined the structure of the human BC domain in complex with soraphen A, a macrocyclic polyketide natural product.

Acyltransferases (ATs) are responsible for the selection and incorporation of acyl building blocks in the biosynthesis of various polyketide natural products.

As part of our ongoing studies into the mechanisms and control of polyketide biosynthesis, we report the second structure of a polyketide synthase ACP.

Although many carrier protein three-dimensional structures have been determined, to date there is no model available for a fungal type I polyketide synthase ACP.

These studies establish the genetic and enzymatic basis for a previously unknown type of polyketide, designated mycoketide, which contains a lipidic pathogen-associated molecular pattern.

Our results indicate that PteF activates the transcription from two promoters of polyketide synthase genes directly, and indirectly of other genes of the cluster.

The polyketide lipid (810.1) was the best biomarker to differentiate the cancer group from control and polyp.

Further, the native gene responsible for the production of macrolactin, the gene encoding polyketide synthase was reduced in copy number after the application of macrolactin.

A synthesis of the ABC-rings of the polyketide natural product hexacyclinic acid has been achieved.

The two essential structural components of macrolide antibiotics are the polyketide aglycone and the appended sugars.

Feeding experiments using (13)C-labeled acetate were carried out to confirm that the angucycline core is indeed polyketide-derived.