1The introduction of a fluorine in position 4 of the xanthene ring improved BACE1 potency (5-10-fold).
2Compared to the previous series, the presence of an aryl moiety at position 4 afforded an average 10-fold increase in potency.
3Concurrent modifications of positions 4 and 8 do not give rise to potent antagonists with reduced partial agonist activity.
4To this end, we have synthesized membrane spanning 23-mer containing a single tyrosyl residue at positions 4, 8, and 12.
5The position , in the French order, of the ships taken in the battle, is shown by the crosses in Positions 4, 5, 6.
Translations for position 4