Significats de premature senescence en anglès

Silencing of YAP inhibits cell proliferation and induces premature senescence.

Individual depletion of these enzymes leads to premature senescence.

In addition, the protective effect of Zfp637 against premature senescence is abrogated in the absence of mTERT.

Diabetic nephropathy is associated with premature senescence.

In this study, we investigated whether AMPK-mediated Cx43 expression and premature senescence in diabetic nephropathy are associated with mTOR activation.

High light induced photooxidation (HLIP) usually leads to leaf premature senescence and causes great yield loss in winter wheat.

Fibroblasts from mutant embryos grew under standard cell-culture conditions but displayed grossly misshapen nuclei, impaired differentiation, increased polyploidy, and premature senescence.

Depletion of CSN5 suppressed cell proliferation, and induced premature senescence characterized by upregulation of senescence-associated-β-galactosidase activity and increased expression of CDK inhibitors.

CO reduced H 2 O 2 -induced premature senescence in human diploid fibroblast WI-38 cells measured with SA-β-Gal-staining.

Ewsr1 deficiency also leads to premature senescence of blood cells and gamete cells with a high rate of apoptosis due to the abnormal meiosis.

Nevertheless, the precise function of Zfp637 has seldom been reported, and it remains unclear whether Zfp637 is involved in oxidative stress-induced premature senescence.

These data indicate that Senp1 repression induces p53-mediated premature senescence and that SUMO proteases may thus be required for proliferation of normal human cells.