Significats de primary aml en anglès

Candidate Ara-C metabolizing gene expression in primary AML cells is proposed to account for this variation.

Avocatin B reduced human primary AML cell viability without effect on normal peripheral blood stem cells.

Genetic knockdown of IRAK1 in primary AML samples and xenograft model showed a significant reduction in leukemia burden.

In addition, the t-AML group had higher rates of relapse and III-IV acute GVHD than the primary AML group.

Our data show that the primary AML samples tested express FAS and DR5 transcripts at levels lower than normal BM.

Together, our data describe a novel role for autocrine IGF-I signaling in the growth and survival of primary AML cells.

FF-10501-01 effectively reduced proliferation at concentrations of 300μM and above in 3 primary AML samples.

Upon treatment of primary AML patient blast cells, the dual inhibition of FLT3 and c-KIT was superior to inhibitors targeting a single RTK.

Most primary AML analyzed were characterized by low BRCA1 mRNA level and undetectable protein expression that likely contributed to explain their sensitivity to olaparib.

The combination decreased the mitochondrial membrane potential as well as expression of Mcl-1 and GPx in primary AML cells more than either drug alone.

Clinically achievable concentrations of olaparib were able to induce cell death in the majority of primary AML case samples (88%) and tested cell lines.

Combination of tunicamycin with potent FLT3ITD kinase inhibitors caused synergistic cell killing, which was highly selective for cell lines and primary AML cells expressing FLT3ITD.