The pope followed his retreating figure with a glance of profound sadness.

Turchi remained silent, gazing upon her with an expression of profound sadness.

The eyes of these three women were filled with a profound sadness.

I had known love contracted by profound sadness or penetrating rage.

It was a sobering conclusion, and it induced a deep and profound sadness.

She heard me with profound sadness, but without manifesting any surprise.

Desgenais understood me; he saw that a profound sadness had taken possession of me.

An air of profound sadness was depicted in his features.

An expression of profound sadness crossed the features of Laihova.

A profound sadness came over the young woman, and tears rushed to her eyes.

Anna Mikháylovna turned up her eyes, and profound sadness was depicted on her face.

A child less fragile, less a reflection of the profound sadness of being alive.

Sir John was perfectly calm, but his face wore a look of profound sadness.

These headstones help tell a small part of this story, a story of profound sadness.

There was profound sadness in the faces of the vast assemblage that crowded the streets.

That will be a moment of profound sadness for many of us across the UK.