Significats de proteasome inhibitors en anglès

That system is a target for anticancer strategies by using proteasome inhibitors.

Nevertheless, the mechanisms of apoptosis induced by proteasome inhibitors remain unclear.

Both Kyprolis and Velcade are members of a class known as proteasome inhibitors.

Overall, these findings suggest proteasome inhibitors as potential latency reversing agents.

Overall, we determined the unique and novel mechanism of FOXM1 suppression by proteasome inhibitors.

Identification of capzimin offers an alternative path to develop proteasome inhibitors for cancer therapy.

We identified proteasome inhibitors as the first type of drugs that target FOXM1 in cancer cells.

This suggests that proteasome inhibitors could also be used for rapidly reducing autoantibody production in autoimmune diseases.

Overcoming resistance of tumor cells to anticancer agents, such as proteasome inhibitors, could improve their clinical efficacy.

These results indicate that p53 downstream targets can collectively modulate apoptotic response to bortezomib and other proteasome inhibitors.

The introduction of newer proteasome inhibitors with activity in bortezomib-resistant disease and reduced toxicity profiles may yield further benefits.

This was confirmed by the lack of inhibition of IAV entry by proteasome inhibitors in a virus-like particle fusion assay.

Pretreatment of DC with proteasome inhibitors strongly enhanced the immunogenicity of single viral synthetic as well as bulk LCL peptides.

This screen identified 100 genes whose knockdown affected lethality to bortezomib and to a structurally diverse set of other proteasome inhibitors.

The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic a …

Moreover, proteasome inhibitors reduced receptor internalization and degradation, thus implicating a role for the ubiquitination machinery in the trafficking of the beta2AR.