Significats de regulate splicing en anglès

These genes regulate splicing, axonal and synaptic function, and are associated with neuropsychiatric disease, suggesting that SAFB1 is an important regulator of key neuronal processes.

This led us to discover NOVA- regulated splicing of cryptic exons within these introns.

The results showed that SRSF10- regulated splicing events are highly evolvable from chickens, mice to humans.

We further show that lead disrupts a neuron- and brain-specific splicing factor NOVA1 regulated splicing network.

Using single-molecule techniques we have determined the stoichiometry of PTB binding to a regulated splicing substrate in whole nuclear extracts.

Our data show that the Rbfox- regulated splicing program plays a crucial role in structural and functional maturation of postmitotic neurons.

Moreover, we used CASH to identify SRSF10- regulated AS events and investigated the evolution of SRSF10- regulated splicing.

With the advent of RNA-sequencing technology, we can detect different types of alternative splicing and determine how DNA variation regulates splicing.

The major class of identified PTB- regulated splicing event was PTB-repressed cassette exons, but there was also a substantial number of PTB-activated splicing events.

We conclude that a significant portion of cassette exons evident in EST databases is not functional, and might result from aberrant rather than regulated splicing.