Significats de renal phosphate en anglès

Affected individuals have isolated renal phosphate wasting and inappropriately normal serum calcitriol concentrations.

Surprisingly, some individuals in group 2 lost the renal phosphate-wasting defect after puberty.

Group 1 consisted of patients who presented with renal phosphate wasting as adolescents or adults.

ADPKD patients with an apparent renal phosphate leak had two-fold higher klotho levels than those without.

The spectrum of disease includes delayed onset of penetrance and loss of the renal phosphate-wasting defect.

Ezrin, a cross-linking protein important for renal phosphate handling, is also involved in the regulation of intestinal calcium absorption.

Our results have implications in the evaluation of patients who present with renal phosphate wasting as either adults or children.

The hallmarks of this disease are isolated renal phosphate wasting with inappropriately normal calcitriol concentrations and a mineralization defect in bone.

Although autosomal dominant transmission of renal phosphate wasting has been described, previous studies included too few affected individuals to adequately characterize the disorder.

Finally, at the end of the review, abnormalities in renal phosphate transport that are sometimes found in patients with polyostotic fibrous dysplasia are discussed.

Thus, common genetic variants located near genes involved in vitamin D metabolism and calcium and renal phosphate transport associated with differences in circulating PTH concentrations.

While such tertiary FGF23 excess and resultant hypophosphatemia typically abates within the first few weeks to months post-transplant, some recipients manifest persistent renal phosphate wasting.

Renal phosphate excretion was normal whereas mild hypercalciuria was found.

Renal phosphate-wasting disorders are the most common form of hereditary rickets and osteomalacia in western countries.