Significats de sclerotic glomeruli en anglès

The number of globally sclerotic glomeruli was averaged across two biopsy sections.

Our goal was to determine the upper limit of normal for number of globally sclerotic glomeruli.

Age, body mass index, BP, and degrees of globally sclerotic glomeruli at biopsy were comparable between the groups.

Quantile regression was used to estimate the 95th percentile for globally sclerotic glomeruli as the upper reference limit.

Smaller cortical volume on imaging correlated with both less cortex on biopsy and higher percentage of globally sclerotic glomeruli.

A simplified model was used to estimate the 95th percentile for number of globally sclerotic glomeruli by total number of glomeruli and age.

Patient variability in percentage of globally sclerotic glomeruli was based on a statistical model because multiple biopsy specimens per patient were not available.

Fewer glomeruli on the biopsy specimen associated with higher mean percentage of globally sclerotic glomeruli and higher patient variability in percentage of globally sclerotic glomeruli.

Numbers of globally sclerotic glomeruli in a kidney biopsy that exceed these thresholds suggest chronic pathological injury in excess of that expected with normal aging.

Conclusions: We have derived the 95% reference limit for number of globally sclerotic glomeruli in ostensibly healthy individuals accounting for age and the biopsy characteristics.