Background: Before 1986, scrubtyphus was only found endemic in southern China.
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Results: Seventy pediatric scrubtyphus cases were included in the study.
3
Results: A total of 480 scrubtyphus cases were confirmed.
4
There have been a few reports on HLH secondary to scrubtyphus in adults.
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Here, we report a case of scrubtyphus presenting symptoms like deep neck infection.
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Orientia tsutsugamushi causes scrubtyphus, a potentially fatal infection that afflicts 1 million people annually.
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Therefore, in endemic areas, a high index of suspicion for scrubtyphus is warranted in patients presenting with HLH.
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Our objective was to document epidemiologic, clinical and laboratory features of pediatric scrubtyphus in this new endemic area.
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Results: A total of 4821 scrubtyphus cases were reported in Guangzhou during 2006-2014.
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This is the first case report of severe neurological impairment resulting from the very rare association of HLH with scrubtyphus.
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This newly recognized scrubtyphus was subsequently reported in many areas of northern China and was then called "autumn-winter type".
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During the autumn-winter period of 1986, a new type of scrubtyphus was identified in Shandong and northern Jiangsu province of northern China.
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The presentation of scrubtyphus mimicking deep neck infection is rarely encountered by clinical physicians and delays the determination of the correct diagnosis.
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Conclusions: The manifestations of pediatric scrubtyphus cases in the novel endemic region of northern China may be less severe than in other regions.
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Leptospirosis and scrubtyphus are major causes of acute febrile illness in rural Asia, where co-infection is reported to occur based on serologic evidence.
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In comparison with the summer type, complications associated with autumn-winter type scrubtyphus were less severe, and abnormalities of routine hematological parameters were less obvious.