Significats de sensitive k en anglès

Our results indicate that this receptor is located extracellularly and modulates ATP- sensitive K+ channels.

The ATP- sensitive K+ channel opener increased Eln gene expression and altered 126 other matrix-associated genes.

Metabolic signals derived from glucose can also stimulate insulin release independent of their effects on ATP- sensitive K(+)-channels.

We also demonstrate that ATP- sensitive K(+) and voltage-dependent calcium channels were required for GPR119-mediated increases in glucose-stimulated insulin secretion.

Pancreatic β cells respond to increases in glucose concentration with enhanced metabolism, the closure of ATP- sensitive K(+) channels and electrical spiking.

As voltage- sensitive K+ channels are major determinants of membrane excitability, one mechanism for generating plasticity is through regulation of K+ channel activity.

Moreover, the antiallodynic and hyperalgesic effect induced by the combination is mediated via the activation of an NO-cyclic GMP-ATP- sensitive K+ channel pathway.

These results suggest that diazoxide activates ATP- sensitive K+ channels of guinea-pig ventricular cells and that cibenzoline, at therapeutic concentrations, inhibits this channel.

The human voltage- sensitive K+ channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the electrocardiogram.

Insulin-secreting pancreatic β-cells are electrically excitable cells that are unusual because their electrical activity is influenced directly by metabolism via ATP- sensitive K+ channels.

ATP- sensitive K(+) channels are gated by intracellular ATP, allowing them to couple intermediary metabolism to cellular excitability, whereas the gating mechanism remains unclear.

Data also suggests that mangiferin activates the NO-cyclic GMP-ATP- sensitive K(+) channels pathway in order to produce its local peripheral antinociceptive effect in the formalin test.

Glucose is the principal stimulator of insulin secretion with the ATP- sensitive K+ channel-voltage-gated Ca2+ channel-mediated pathway being the primary one involved in glucose-stimulated insulin secretion.