Significats de sensitize mice en anglès

Results: Upon oral BLG challenge, orally sensitized mice developed only mild clinical signs.

However, nasal histology of the ovalbumin- sensitized mice showed no increase in eosinophil infiltration.

Neutralizing antibody against TNF-alpha prevented antigen-induced eosinophil recruitment into the BALF of sensitized mice.

Methods: Cross-reactivity model: Cashew- sensitized mice underwent immunotherapy with cashew and were subsequently challenged with cashew and pistachio.

Similar results were obtained when apoptotic liver damage was induced by administration of tumor necrosis factor-alpha to d-galactosamine- sensitized mice.

Sensitized mice were SLIT-treated and subsequently challenged intranasally and analysed for clinical symptoms, antibody levels, eosinophilia and T cell response.

Hepatocyte-specific inactivation of hnRNPU disrupted liver chromatin accessibility, activated molecular signature of NASH, and sensitized mice to diet-induced NASH pathogenesis.

Conclusions: Tumor necrosis factor-induced hepatic apoptosis followed by necrosis may represent a general pathomechanism of T-cell shock models using D-galactosamine- sensitized mice.

Protection could also be transferred to sensitized mice via serum or via CD25-positive CD4 T cells.

Liver injury associated with apoptotic cell death and DNA fragmentation was also noted in D-galactosamine- sensitized mice injected with staphylococcal enterotoxin B.

Similar results were found in galactosamine- sensitized mice in an inflammatory liver model using the superantigen staphylococcal enterotoxin B as a T-cell activator.

Results: Intranasal challenge of sensitized mice led to the development of rhinitis characterized by significantly increased sneezing and influx of eosinophils into the nose.

However, supplementary protein therapy revealed that gene transfer had sensitized mice to hFVIII in a high-responder strain but not in mice of a low-responding strain.