Significats de somatic stem en anglès

Highly tumorigenic subpopulations of several solid cancers share characteristics with somatic stem cells.

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity.

Yet, many cells retain properties of differentiated epithelial cells and lack central properties of somatic stem cells.

Human pluripotent stem cells are a renewable source for any adult cell types, including somatic stem cells.

One hypothesis suggests that the somatic stem cells of the liver, the so-called oval cells, may undergo malignant transformation.

Generation of somatic stem cells from human pluripotent stem cells is a promising strategy to get these therapeutically valuable cells.

This is accompanied by tegument disruption and an arrest of mitotic activity in somatic stem cells and germ line tissues.

Several somatic stem cell populations are dysfunctional in Down syndrome and their deficiencies may contribute to multiple Down syndrome phenotypes.

How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains a black-box in cell biology.

The retinoblastoma tumor suppressor gene Rb is essential for maintaining the quiescence and for regulating the differentiation of somatic stem cells.

Advancements in stem cell biology, including embryonic and postnatal somatic stem cells, have made the prospect of tissue regeneration a potential clinical reality.

Inactivation of Rb in somatic stem cells typically leads to their overexpansion, often followed by increased apoptosis, defective terminal differentiation, and tumor formation.

Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells.

Skeletal muscle is a dynamic tissue that is capable of adapting to stress and severe injury due to a resident somatic stem cell population.

In this study, we used a prospective isolation method of somatic stem cells from gestational or fat tissues, which were identified using CD73 antibody.

These studies enhance the understanding of the regulatory mechanisms that direct the somatic stem cell populations and the role they play in development and regeneration.