Significats de specific enhancers en anglès

Conclusions: The transcription factor ERG promotes endothelial homeostasis via regulation of lineage- specific enhancers and super-enhancers.

We demonstrated that CHD1 occupied prostate- specific enhancers enriched for the androgen receptor (AR) and lineage-specific cofactors.

Interactome maps connecting disease-risk variants in cell-type- specific enhancers to promoters revealed an extended microglia gene network in AD.

Liver- specific enhancers were observed to be methylated in cortex, while cortex specific enhancers were methylated in the liver.

However, cell class- specific enhancers are distinguished by enrichment of E-box motifs in bipolar cells, and Q50 homeodomain motifs in photoreceptors.

We found a distinct genomic distribution of 5hmC in cfDNA marking tissue- specific enhancers, consistent with their putative roles in gene regulation.

Eight of nine regions function as blood- specific enhancers in zebrafish, of which two were previously shown to harbour blood-specific enhancer activity in mice.

Analysis of reactivated regulatory elements enabled the identification and functional validation of previously unknown metastasis- specific enhancers at HOXB13, FOXA1 and NKX3-1.