Significats de stall forks en anglès

Stalled forks at dysfunctional human telomeres are likely to accelerate the genomic instability that drives tumorigenesis.

At stalled forks, CMG removal results in fork breakage and end joining events involving deletions and templated insertions.

Mutational analysis suggests that multisite ubiquitination of the entire RPA complex is responsible for repair at stalled forks.

Our findings reveal a similar requirement for multisite protein group ubiquitination during HR at stalled forks in mammalian cells.

Taken together, our results identify a previously unanticipated role for Pol kappa in promoting DNA synthesis and replication stress recovery at sites of stalled forks.