Significats de striatal dopamine en anglès

Participants then completed a decision-making task that is diagnostic of striatal dopamine dysfunction.

No change was noticed in striatal dopamine release or turnover.

Cocaine enhanced the levels of striatal dopamine produced by electrical stimulation of dopaminergic neurons.

Moreover, both manipulations also reduced striatal dopamine release and blunt postsynaptic responses to D2R antagonists.

We, therefore, used this test to examine behavioral deficits as a function of striatal dopamine loss.

The major abnormal result observed is the significantly reduced uptake in striatal dopamine transporter density and activity.

Our findings point to a causal link between striatal dopamine signaling and the outcomes of bariatric interventions.

However, we did not find any correlation between reward effects on cognitive control and striatal dopamine synthesis capacity.

These results suggest that striatal dopamine reuptake may occur outside of synaptic specializations once dopamine diffuses from the synaptic cleft.

In vivo, it was revealed that PC treatment inhibited striatal dopamine depletion, which resulted in significant improvements in PD-like movement impairment.

These results indicate that in rats, reward responsiveness can be quantified and bidirectionally modulated by pharmacological manipulations that alter striatal dopamine transmission.

Purpose: The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects.

Objective: The authors examined whether subjects with Tourette's disorder have greater than normal striatal dopamine transporter densities, as suggested by previous post-mortem findings.

Methylphenidate boosted choices of cognitive effort over leisure across the group, and this effect was greatest in participants with more striatal dopamine synthesis capacity.

There was a robust decline in striatal levels of 3, 4-dihydroxyphenylacetic acid without a significant depletion of striatal dopamine.

PMID: 23232506 PURPOSE: The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects.