Significats de synthetic lethality en anglès

These results form a computational basis for exploiting synthetic lethality to uncover cancer-specific susceptibilities.

Finally, we identify synthetic lethality arising from gene overactivation and use it to predict drug efficacy.

Combining mutant alleles of CPL1 and CPL2 causes synthetic lethality of the male but not the female gametes.

The quinazolinone derivative erastin was originally identified in a screen for small molecules that exhibit synthetic lethality with expression of the RAS oncogene.

Consistent with a critical role for ATM in HDR in this background, loss of ATM leads to synthetic lethality of Brca1S1598F mice.

The synthetic lethality of sod1Δ Pma1-T912D cells is suppressed by growing cells under low oxygen conditions or by treatments with manganese-based antioxidants.

In a process called " synthetic lethality", Parry and his team are trying to find the vulnerabilities caused when certain genes are mutated in cancer cells.

Synthetic lethality occurs when the inhibition of two genes is lethal while the inhibition of each single gene is not.