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Chemical compound.
rtdp
ribosylthymidine diphosphate
ribothymidine 5'-diphosphate
ribosylthymidine 5'-diphosphate
ribosylthymine diphosphate
ribosylthymine 5'-diphosphate
chemical compound
1
However, the mechanism by which
TDP
-
43
mutations lead to neurodegeneration is unclear.
2
Results: We identified multiple phosphorylation sites in carboxyl-terminal regions of deposited
TDP
-
43
.
3
This is consistent with new emerging ideas about
TDP
-
43
functions in dendrites.
4
We recently identified
TDP
-
43
as the major pathological protein in sporadic ALS.
5
Moreover, enforced repression of cryptic exons prevented cell death in
TDP
-
43
-
deficient
cells.
6
Previous studies reported that abnormal phosphorylation takes place in deposited
TDP
-
43
.
7
However, no prior studies have investigated the interactions between
TDP
-
43
oligomers and tau.
8
TDP
-
43
inclusions were found in each region of all the cases.
9
Interestingly, patients with
TdP
exhibit more bradycardia as such with VT.
10
We found no associations between atherosclerosis ratings and a-synuclein or
TDP
-
43
lesion ratings.
11
How increased and disease-causing mutant forms of
TDP
-
43
induce cell death remains unclear.
12
Accumulation of
TDP
-
43
is associated with neuronal death in the brain.
13
The
TdP
events are not concentrated in the first week.
14
Autopsy in three family members showed a consistent and unique subtype of
FTLD
-
TDP
pathology.
15
These findings may have important implications for accumulated or mutant
TDP
-
43
induced neurodegenerative diseases.
16
Pathological
TDP
-
43
was present only rarely in the CO group.
tdp
cytoplasmic tdp
pathological tdp
deposit tdp
mutant tdp
phosphorylate tdp