Significats de transcriptional enhancers en anglès

Developmental gene expression patterns are orchestrated by thousands of distant-acting transcriptional enhancers.

The identification of transcriptional enhancers has proven rather difficult by conventional experimental approaches.

In this review we discuss how recent epigenomic studies have provided insights into the function of transcriptional enhancers.

Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage-specific transcription factors driving expression of genes that define cell identity.