Significats de truncate ar en anglès

Analysis of human prostate tumors indicates that several tumors express higher levels of this truncated AR than noncancerous prostate tissue.

In transient transfection studies, the truncated AR is three to five times more potent than the full-length receptor in transactivating transcription.

The androgen-independent Rv1 cells express high levels of the truncated AR, and treatment of these cells with a calpain inhibitor reduces truncated AR expression.

Whereas full-length AR requires Hsp90 and importin-β for active nuclear translocation, basal nuclear localization of truncated AR variants is independent of these classical signals.

Despite loss of this NLS, we show that diverse truncated AR variant species have a basal level of nuclear localization sufficient for ligand-independent transcriptional activity.

This modeling revealed that these AR gene rearrangements blocked full-length AR synthesis, but promoted expression of truncated AR variant proteins lacking the AR ligand-binding domain.