1
Equilibrium dialysis and ultrafiltration were used and compared with separate unbound fraction.
2
Also, the unbound fraction determined at each sampling time did not vary significantly between the treatments.
3
No alterations in drug clearance or unbound fraction with age, frailty, or p16INK4a expression were observed.
4
The concentration of active protease inhibitor available for binding with HIV-1 protease was assumed equal to the unbound fraction in the plasma.
5
The unbound fraction of ceftriaxone ranged between 14% and 43%, with a higher unbound fraction present at higher total concentrations.
6
We have recently developed a method that during near in vivo conditions isolates the free, unbound fractions of IGF-I and IGF-II in human serum.