Significats de unclassified variants en anglès

All variants tend to be polymorphisms and unclassified variants.

We examined 10 BRCA1 and 15 BRCA2 unclassified variants identified in Australian, multiple-case breast cancer families.

This combination of analyses may have direct application to the characterisation of other unclassified variants in BRCA1 and BRCA2.

Twenty-three different mutations were detected in 30 individuals, ten were deleterious mutations and 20 were " unclassified variants" with uncertain clinical consequences.

The 55 non-truncating variants included 3 unclassified variants predicted to affect protein product and not co-occurring with a truncating mutation in the same gene.