Significats de ureteric bud en anglès

Development of the metanephric kidney depends on precise control of branching of the ureteric bud.

Double mutant mice showed significant recovery of ureteric bud branching and ENS development in the stomach.

The metanephric mesenchyme-derived signals that control gene expression at the ureteric bud tip are not well understood.

HoxB7Cre-mediated removal of Dicer function from the ureteric bud epithelium led to the development of renal cysts.

This was preceded by excessive cell proliferation and apoptosis, and accompanied by disrupted ciliogenesis within the ureteric bud epithelium.

The genes implicated have been shown to regulate the reciprocal induction between the ureteric bud and the metanephric mesenchyme.

They are also required for the normal nephrogenesis response of the metanephric mesenchyme to inductive signals from the ureteric bud.

They are expressed in the early metanephric mesenchyme and are required for the induction of ureteric bud formation and its subsequent branching morphogenesis.

These studies indicate that Sall1-dependent signals from the metanephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate branching.

Forty-eight hours later, ureteric buds were elongated and initial branching was completed.