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1
Although we previously reported that receptor inhibition usingsiRNA or chemical inhibition obliterates the viability of melanoma cells, the mechanism was unclear.
2
RNA interference studies usingsiRNA or shRNA confirmed that lowering GCS expression in tumor cells did not affect their responsiveness to commonly used cytotoxic drugs.
3
PTIG1 gene silencing usingsiRNA may be an effective modality to treat liver cancer, in which PTTG1 is abundantly expressed.
4
UsingsiRNA to silence Blimp-1, we further elucidated the regulatory role of Blimp-1 in the TIGIT and PD-1 expression and T cell immune response.