Significats de vascular remodelling en anglès

Prior studies have demonstrated that uric acid directly contributes to vascular remodelling and endothelial dysfunction.

Objective: To determine whether plaque composition at the dilated site affects probucol-induced vascular remodelling after angioplasty.

Conclusion: Plaque composition at the dilated site does not appear to influence probucol-induced vascular remodelling after angioplasty.

Aims: Pulmonary arterial hypertension is a devastating disease characterised by pulmonary vascular remodelling and right heart failure.

These findings support a hypothesis that pathways involved in systemic vascular remodelling play a role in AAA development.

Current treatments increase life expectancy but have limited impact on the progressive pulmonary vascular remodelling that drives PAH.

Conclusions: Common variation at 1q24.3 is associated with expansive vascular remodelling and risk of AAA.

Treprostinil also reduced right ventricular systolic pressure and slightly reduced the vascular remodelling but failed to reverse the right ventricular hypertrophy.

Conclusions and implications: Co-administration of FO and low-dose aspirin may act synergistically to protect against thrombosis and injury-induced vascular remodelling in mice.

In summary, we show that circulating fibrocytes contribute to hypoxic pulmonary vascular remodelling and may be specifically targeted by a prostacyclin analogue.

Both genetic and mechanistic studies have succeeded in identifying new molecular pathways relevant to the process of pulmonary vascular remodelling, which underlies PPH.

It also appears likely that endothelin participates in the adverse cardiac and vascular remodelling of hypertension, as well as in hypertensive renal damage.

Our findings appreciate the grape skins as rich source of polyphenols able to prevent the dysregulation of vascular remodelling affecting degenerative and inflammatory diseases.