Significats de vp16 en anglès

The different uterine drug accumulation of VP16 and L-V contributed to partly cause for the functional variation.

We generated transgenic mice expressing a constitutively active VP16-LXRa protein from the aP2 promoter.

Moreover, VP16-LXRa expression also suppressed the induction of inflammatory genes by lipopolysaccharide to a comparable degree as synthetic agonist.

The herpesvirus VP16 transactivator has become a useful tool for facilitating the production of recombinant proteins in cultured mammalian cells.

We demonstrate that 24 h of exposure to XK469 before VP16 resulted in a maximum synergistic response.

Using a chimeric ER-VP16 construct, we demonstrate that both pure antagonists and partial agonists deliver ER to its DNA target within cells.

Arm A consisted of oral VP16 daily for up to 21 days with cycles repeated every 35 days.

To explore this potential, we undertook a prospectively randomized three-arm trial in a phase I setting with various schedules of VP16 and GM-CSF.

Fusion of the Vp16 activation domain to full-length T-bet greatly increases its activation of both endogenous IFNgamma and transfected T-site reporter gene expression.

We have engineered mammalian cell lines to produce high levels of heterologous proteins by constructing a cell line that expresses the herpesvirus transactivator, VP16.

To understand the mechanisms of combined DHA and VP16 on MB cells, pathway specific oligo array analyses were performed to dissect possible signaling pathways involved.

The rate for the TFIIB-TBP-DNA complex formation is accelerated drastically by GAL4-VP16 and is also dependent on the type of promoter sequences.

Moreover, the ability of VP22 to bind VP16 enhanced but was not fundamental to the rescue of vhs-induced nuclear retention of late transcripts.

A chimeric VP16-Tat construct containing the leucine mutations showed no increased AP-1 responsiveness in comparison with that of the VP16 activation domain alone.

Two other virus proteins-VP22 and VP16 -are proposed to regulate vhs to prevent uncontrolled and lethal mRNA degradation but their mechanism of action is unknown.

U87 and U138 cells were found to be insensitive to the addition of DHA and VP16, whereas the two MB cell lines showed high sensitivity.