Significats de vp4 en anglès

Reactivity with polyclonal and monoclonal antibodies suggested that neutralizing epitopes were functionally unaltered on the expressed VP4.

Moreover, two amino acid substitutions observed in the VP4 gene were conserved between two or more strain pairs.

WIN 52035-2 was found to inhibit the first step of uncoating, release of VP4.

The membrane permeability induced by recombinant VP4 was influenced by pH and was comparable to permeability induced by infectious virions.

The outer capsid proteins VP4 and VP7 are highly variable and represent the major neutralizing antigens.

In this study, we have produced recombinant C-terminal histidine-tagged human rhinovirus VP4 and shown it can induce membrane permeability in liposome model membranes.

The complete VP4 gene of porcine rotavirus strain OSU has been inserted into a baculovirus expression vector under the control of the polyhedrin promoter.

The VP4 produced in this system also induced antibodies in guinea pigs which inhibited hemagglutination of OSU and neutralized its infectivity to high titer.

Thirty percent of samples in this study were mixed infections and 21 (16.7%) specimens remained untypeable either for the VP7 or for the VP4 gene.