1
Premature or aberrant activation of NF-kappaB may thus contribute to preterm labour.
2
The aberrant activation of this pathway is a major event in human hepatocellular carcinoma.
3
Our results demonstrate that aberrant activation of the GIMAP enhancer contributes to T-cell leukemogenesis.
4
This work suggests a new therapeutic strategy against human cancers caused by aberrant activation of β-catenin.
5
Previous studies report aberrant activation of the hedgehog signaling pathway in the progression of various cancers.
6
In mice with aberrant activation of β-catenin signaling, Wnt signaling also controls hepatocyte proliferation through a non-cell-autonomous mechanism.
7
Dysregulation of mRNA translation leads to aberrant activation of cellular pathways that promote expansion and survival of leukemic clones.
8
These findings may have general applicability in cancer therapy, because aberrant activation of PI3K occurs frequently in human cancer.
9
We thus provide evidence that the aberrant activation of the IL-2 autocrine circuit can lead T cells to malignant transformation.
10
Growing evidence illustrates that aberrant activation of the epithelial-mesenchymal transition plays a key role in tumor cell invasion and metastasis.
11
Loss of PRC2 leads to aberrant activation of a microglia clearance phenotype, which triggers changes in neuronal morphology and behavior.
12
In contrast to other pancreatic tumours, aberrant activation of the Wnt-beta-catenin pathway appears to be a constant feature in SPN.
13
Mutation of various cell signaling molecules or aberrant activation of signaling pathways leads to poor response to chemotherapy in CRC.
14
Our data show that both primary and secondary exposures to hepadnavirus induce aberrant activation of lymphocytes preceding the virus-specific T-cell response.
15
Multiple lines of evidence implicate that aberrant activation of Hedgehog (Hh) signaling is involved in a variety of human cancers.
16
Wider implications of the findings: Our results imply that aberrant activation of STAT3 signaling plays an important role in the pathogenesis of endometriosis.
