Mutation of the GATA motifs to abrogatebinding of this factor reduced the regulatory activity of the element.
2
CRP bound in DRaCALA specifically to (32)P-labeled oligonucleotides containing the consensus CRP binding site, but not to oligonucleotides with point mutations known to abrogatebinding.
3
Mutation of the Ets binding motifs to abrogatebinding of this factor reduced the regulatory activity of the +22.6-kb site.