Meanings of acquired mutations in English

Errors during DNA replication contribute to the development of acquired mutations.

The presence of subclonal diversity was confirmed at a single-cell level using other tumor- acquired mutations.

Somatically acquired mutations in several genes have been reported as playing an important role during colorectal tumorigenesis.

Senescence is subsequently induced in cells with acquired mutations while, in their absence, polyploidy is followed by cell death.

Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood cancers1-10.

Although one of these compounds, vismodegib, is now FDA-approved for patients with advanced basal cell carcinoma, acquired mutations in Smo can result in rapid relapse.

This study explores the hypothesis that acquired mutations of c-kit in the hematopoietic stem cell participate in the pathogenesis of aplastic anemia (AA).

Here we show that at least 20% of cervical cancers harbor somatically- acquired mutations in the LKB1 tumor suppressor.

In addition, the mitochondrial genome seems to be particularly prone to DNA damage and acquired mutations may have a role in ageing, cancer and neurodegeneration.