Meanings of activate mutations in English

Activating mutations in ras genes are a common genetic abnormality in human malignancies.

About a third of these tumours presents activating mutations of the β-catenin gene.

Activating mutations were not detected in cDNA encoding the RTKs in HRS cell lines.

It is characterized by activating mutations in the tyrosine kinase genes c-kit or PDGFRA.

Activating mutations of the Kras gene are common to the vast majority of human PDA.

A mutually exclusive subset harbors activating mutations in JAK2.

They include activating mutations or gene amplification for c-Met and constitutively active splicing variants for RON.

Importantly, although kinase activation represents a common theme in neoplasias, not all activating mutations are functionally equivalent.

Activating mutations of the Wnt signaling pathway have been observed in more frequent cancers, particularly digestive tract tumors.

Background: The application of genomic technologies to patient tumor samples identified groups of signaling pathways which acquire activating mutations.

Activating mutations of RAS frequently occur in subsets of human cancers, indicating that RAS activation is important for tumorigenesis.

Approximately 85% of GISTs harbor activating mutations in KIT or the homologous receptor tyrosine kinase PDGFRA gene.

We identified three GIST patients with heterozygous KIT- activating mutations at initial presentation, who later recurred with highly aggressive clinical courses.

Additionally, activating mutations in c-Met kinase domain have been reported in a subset of familial cancers causing resistance to treatment.

Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites.

Activating mutations in RAS are among the most common oncogenic drivers in human cancers, with KRAS being the most frequently mutated oncogene.