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1
In summary, PMA-differentiated THP-1 macrophages did not entirely reproduce the response spectrum of primary MDMs to
activating
stimuli
.
2
In fact, the blood monocytes from these patients did not even respond to optimal
activating
stimuli
in vitro.
3
Platelet metabolism is affected by age and it is critical to platelet responses to
activating
stimuli
in an age-dependent manner.
4
Hyperchromatism was shown only in the presence of the
activating
stimuli
or within a very short time after they had been received.
5
While in 12 of them THP-1 and MDM showed comparable trends, for the remaining 17 proteins their responses to
activating
stimuli
did markedly differ.