Combined treatment of LPS and OVA restored body weight loss and further ameliorated the severity of acute DSS colitis.

Moreover, heat-killed Nissle1917 or its genomic DNA alone also ameliorated the acute DSS colitis and viable bacteria macro- and microscopically.

Results: LPS administration significantly attenuated the severity of acute DSS-induced colitis as assessed by DAI and histopathologic scoring compared with the control group.