Interventions that improve self-care confidence may be particularly important in older adults with moderate to advanced HF.

This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support.

We sought to determine the association between noncardiac comorbidities and HRQOL in ambulatory patients with advanced HF.

Conclusions: This study represents the largest report to date of women with ambulatory advanced HF receiving contemporary therapies.

The aim of the study is to better understand disease trajectory and optimal timing of advanced HF therapies.

The eNO may be an easily obtainable and quantifiable measure of the response to therapy in advanced HF.

Conclusions: Hormone replacement therapy is associated with a marked improvement in survival in postmenopausal women with advanced HF.

Lipidomic analysis revealed increased total and very long-chain ceramides in myocardium and serum of patients with advanced HF.

Conclusions: In chronic systolic HF, elevated plasma MPO levels are associated with an increased likelihood of more advanced HF.

Conclusions: Advanced care planning that seamlessly bridges hospital and home must be standard care for patients who have advanced HF.

Objective: To identify, from the patient's perspective, the major opportunities for improving EOL care for patients hospitalized because of advanced HF.

This study is designed to investigate safety and biological effects of enzyme replacement using gene transfer in patients with advanced HF.

Conclusions: While noncardiac comorbidities were prevalent in ambulatory advanced HF patients, only depression was associated with decreased generic and HF-specific HRQOL.

Conclusions: We tailored and demonstrated feasibility of providing an early, concurrent palliative care intervention to patients with advanced HF and their caregivers.

In conclusion, the findings demonstrate the beneficial effects of a low-level, home-based walking program on weight loss in overweight and obese patients with advanced HF.

UPR activation and apoptosis are reduced after mechanical unloading, which may be mediated by the improvement of Ca(2+) handling in patients with advanced HF.