These tumours are characterised by an aggressive phenotype and poor clinical outcome.

We found that deregulation of miR-506 in ovarian carcinoma promotes an aggressive phenotype.

As the mechanistic basis for this aggressive phenotype is unclear, treatment options are limited.

This aggressive phenotype of ectodomain EGFR expressing tumors was confirmed in the independent cohort.

However, tumors treated with anti-androgens frequently become hormone refractory and acquire a more aggressive phenotype.

PLVI denotes an aggressive phenotype, suggesting that these patients may benefit from adjuvant systemic therapy.

Depletion or drug-induced inhibition of Ring1b promoted tumour cell reprogramming towards a less aggressive phenotype.

All of these other major chromosomal abnormalities only occurred in tumors demonstrating a more aggressive phenotype.

In high-grade glioma VEGFR-1 expression by tumor endothelium and neoplastic cells contributes to the aggressive phenotype.

Additionally, it may exert a selection pressure, allowing expansion of tumor cells with a more aggressive phenotype.

This indicates a clinically less aggressive phenotype.

Here, we highlight changes in KRAS and TP53 genes that are normally associated with a more aggressive phenotype.

Defects in DNA repair pathways enable cancer cells to accumulate genomic alterations that contribute to their aggressive phenotype.

Rab25, a receptor recycling protein, has been reported to be enhanced in tumors with aggressive phenotype and chemotherapy resistance.

Recent reports have suggested that putative cancer stem cells exist in ES and may contribute to an aggressive phenotype.

Aim: To identify whether positive resection margin tumours had a more aggressive phenotype, using tumour micro-vessel density and invasive margin.