Major mechanical trauma causes a severe suppression of B-cell differentiation and IgM synthesis in mononuclear leukocyte cultures.

Conclusion: Recurrent preterm birth was associated with decreased peripheral blood mononuclear leukocyte production of interleukin-10 in response to a stimulus during the second trimester.

Flow cytometry was used to analyze alterations in the level of mononuclear leukocytes.

At a protein and mRNA level we were able to show that endothelin-1 is produced by mononuclear leukocytes.

However, recent papers report that phototherapy increased apoptosis in peripheral mononuclear leukocytes in vivo and in mouse lymphoma cell line in vitro.