Switching on the transgene promotes robust antidepressant and anxiolytic effects in both lines.

In contrast, ethanol and fluoxetine had robust anxiolytic effects, including increased exploration and reduced erratic movements.

These findings confirm the antidepressant-like potential of SSR149415 and suggest that it may also have anxiolytic effects.

Our findings suggest that anxiolytic effects of ASH occur via the regulation of autonomic function and increased hippocampal BDNF signaling.

Oxytocin produces anxiolytic effects via the central nucleus of the amygdala but how the peptide reaches its receptors in this region has been unclear.