This study aimed to determine whether GBE would improve aortic dilation and rupture rate of AngII-induced AAAs.

GBE also did not attenuate either aortic rupture or progressive aortic dilation in mice with established AAAs.

Young patients with BAV can have significant aortic dilation that places them at risk for morbidity and mortality.

Doxycycline administration did not prevent progressive aortic dilation as determined by temporal measurements of lumen dimensions using high frequency ultrasound.

Background: Congenital aortic valve fusion is associated with aortic dilation, aneurysm, and rupture in girls and women with Turner syndrome.

Although a majority of young patients with BAV also have some aortic dilation, interventions on the aorta are very rare during this time frame.

Recently, an abnormality in the process of matrix microfibrillar component remodeling has been advocated as a mechanism involved in the development of aortic dilation.

Conclusions: In bicuspid-associated aortic dilations, an asymmetric pattern of matrix protein expression was found that was consistent with the asymmetry in wall-stress distribution reported previously.