1
Loss of apico- basal polarity often results in a malignant phenotype in epithelial tissues.
2
Apico- basal polarity is a hallmark of epithelial tissues.
3
The growth of a well-formed epithelial structure is governed by mechanical constraints, cellular apico- basal polarity, and spatially controlled cell division.
4
Apical- basal polarity is essential for the formation and function of epithelial tissues, whereas loss of polarity is a hallmark of tumours.
5
Planar cell polarity or PCP refers to a uniform cellular organization within the plan, typically orthogonal to the apico- basal polarity axis.
6
By definition, all epithelial cells have apical- basal polarity, but it is unclear how epithelial polarity is acquired and how polarized cells engage in tube formation.