Meanings of base optimization in English

Through structure- based optimization, potent compounds were obtained with significantly improved activity.

Its crystal structure was used as starting point for a structure- based optimization in this study.

The third VMAT plan was generated using the Pinnacle SmartArc IMRT module which is an aperture- based optimization method.

However, for many of these hits, the cellular target has not yet been identified, thus preventing further target- based optimization of the compounds.

Structure- based optimization yields PZM21-a potent G i activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment.

Through reward- based optimization, we use the internal model to search for a better movement plan to minimize implicit motor costs and maximize rewards.

Structure- based optimization efforts led to Cat S inhibitors such as 5 and 9 with greatly improved potency and drug disposition properties.