The basichelix-loop-helix myogenic regulatory factors play critical roles in skeletal myogenesis.
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The TWIST family is a group of highly conserved basichelix-loop-helix transcription factors.
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The basichelix-loop-helix transcription factor Olig2 is required for oligodendrocyte specification and differentiation.
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TWIST2 encodes a basichelix-loop-helix transcription factor that regulates the development of mesenchymal tissues.
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MITF is a basichelix-loop-helix leucine zipper-type transcription factor and is important for development of mast cells.
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MITF is a basichelix-loop-helix leucine zipper transcription factor, which is important for normal phenotypic expression of mast cells.
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The family of basichelix-loop-helix (bHLH) genes comprises transcription factors involved in many aspects of growth and development.
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Background: Proneural genes encode basichelix-loop-helix transcription factors that specify distinct neuronal identities in different regions of the nervous system.
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Olig1 is a basichelix-loop-helix (bHLH) transcription factor generally used as a lineage tool for oligodendrocyte research in spinal cord.
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Merkel cells are mechanosensitive skin cells derived from the epidermal lineage whose development requires expression of the basichelix-loop-helix transcription factor Atoh1.
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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the family of basichelix-loop-helix transcription factors.
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HES-5 is a mammalian basichelix-loop-helix factor that has a distant sequence homology to the product of the Drosophila pair-rule gene hairy.
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Sterol regulatory element binding proteins (SREBPs) are a class of basichelix-loop-helix transcription factors that regulate diverse cellular responses in eukaryotes.
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It has also been shown that the basichelix-loop-helix (bHLH) transcription factor Math1 is a positive regulator of hair cell differentiation.
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Purpose: The helix-loop-helix protein Id-1 serves to prevent basichelix-loop-helix transcription factors from binding to DNA, thus, inhibiting the transcription of differentiation associated genes.
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Myogenic factors and TAL1 possess distinguishable DNA binding characteristics when they form a complex with basichelix-loop-helix (bHLH) proteins of class A.