Competitive sports and vigorous exercise are contraindications in almost all patients.

A history of coronary artery disease, vascular disease, stroke or thromboembolism are contraindications for HST.

Syphilis contracted late in the pregnancy, and tuberculosis, are contraindications, owing to the danger of the mother infecting the child.

Intravenous thrombolysis with rtPA should be administered within 4.5 hours from symptom onset, except when there are contraindications.